Endocrine Abstracts

Mitochondria, which are essential organelles for endocrine health, plays an important role in various physiological functions including hormonal biosynthesis, cell metabolism, proliferation and differentiation. Thus, mitochondrial toxicity can affect a variety of organs, such as liver, heart, muscle, kidney, and central nervous system. Mitochondrial toxicity is recognized as a contributor to drug-induced toxicity of various drugs such as hydroxytamoxifen, valproic acid, acetam...

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...

Objectives: The aim of this study was to evaluate the diagnostic performance of biopsy criteria in four society ultrasonography (US)-based risk stratification systems (RSSs) or thyroid imaging reporting and data system (TIRADS) including the 2021 Korean (K)-TIRADS for thyroid nodules.Methods: Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched and other eligible articles by manual search were included to identify original articles invest...

Introduction: About 12% of patients present to the GPs with hypertension or related symptoms. The current practice of managing resistant hypertension in primary care is inconsistent and general practitioners (GP’s) do not have a criteria for referral to tertiary care.Methods: Quantitative anonymized online survey of 26 questions on the current prescribing practices and thresholds for referral of resistant hypertensi...

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...

Introduction: The mortality rate from cardiovascular disease (CVD) among young adults has declined less than that in the older population, raising concerns about the increasing prevalence of obesity-related conditions including hypercholesterolemia in the younger population. We investigated the age-standardized mean levels of serum cholesterols and the prevalence, awareness, treatment and control rates of hyper-LDL-cholesterolemia based on age.Methods: N...

Intrathyroidal thymic carcinoma (ITTC) is a rare thyroid malignancy. Its histology resembles that of squamous cell carcinoma (SCC) of the thyroid. However, ITTC shows a much more favorable prognosis than SCC. We analyzed the backgrounds and clinicopathological features of 10 patients who treated with ITTC in our medical center. Five patients was male, and another five was female. The average tumor size was 4mm, and it ranged from maximum 68mm to minimum 13mm. In pre-operative ...

Background: Anaplastic thyroid carcinoma (ATC) is associated with the highest mortality risk of any thyroid-arising tumor; however, there is currently no effective therapy for ATC, and multimodal therapy is associated with a relatively high mortality risk. Here, we investigated the effects of neoadjuvant chemoradiotherapy on patients with ATC treated with paclitaxel and intensity-modulated radiation therapy (IMRT).Methods: The medical records of 157 pati...

Background: We aimed to explore the relationship between continuous glucose monitoring (CGM)-derived indicators and the presence of albuminuria taking circadian features into consideration concurrently in Insulin-using patients with type 2 diabetes.Methods: We analyzed data from 129 insulin-treated type 2 diabetes patients in Korea University Ansan Hospital. Over 10 days, we collected time-series data using Dexcom G6, Fitbit, and food diaries, along with...

Large animals are increasingly used a models for endocrine research. Unlike rodents they are cortisol-dominant and thus more similar to humans. In this study we use two novel analytical methods to compare the steroid profile of pigs, sheep and humans; 1. Simultaneous quantification of primary glucocorticoids, glucocorticoid precursors and mineralocorticoids in plasma (>20 steroids); 2.Quantification of glucocorticoids metabolites (>10 ...